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Circadian Rhythm Disruption as a Root Cause of DepressionCircadian clock gene variants in CLOCK, BMAL1, PER, CRY, NPAS2, and OPN4 interact with light exposure to disrupt hormones, sleep, and mood, increasing risk for depression, anxiety, and seasonal affective disorder

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It is possible that such minor gene effects may be additive and particular combinations of polymorphisms from different genes may confer neuroprotection

Xia, B., Krutkramelis, K